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M2 activation state expresses anti-inflammatory cytokines, arginase-1 (Arg1), transforming growth factor 1 (TGF1), CD206 and Chitinase-3-like-3 (YM-1 in rodents) (Figure 6L)

Most patients begin to notice subtle effects in the first month, but significant results, such as increased lean muscle mass, reduced body fat, and enhanced HGH levels, typically take three to six months to develop fully

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Laboratory studies investigate its mechanisms at the cellular level, including receptor binding, signal transduction, and gene expression pathways