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(167) found that vitreous humor secretes Glia maturation factor- (GMFB) in a high-glucose environment, which in turn translocates the ATPase H + Transporting V1 Subunit A(ATP6V1A) from lysosomes, alkalizes lysosomes in RPE cells, and the ACSL4 protein ends up being digested in lysosomes, where an abnormal autophagy-lysosomal degradation process leads to the production of lipid species and ultimately induces ferroptosis in RPE

Oxidative stress typically comes as a secondary stress after primary stresses, whether they are abiotic constraints ( Figure 4 ), such as drought or flooding, wounding, high light, cold or heat stress or biotic stresses including pest attacks or bacterial and fungal infections

and (4) the AsA-GSH pathway catalyzed by ascorbate peroxidase (APX) at the expense of ascorbic acid (AsA)

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