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It seems that chemotherapy regimens (drug or combination of drugs administered and dosing), methods of pain assessment and the individual patient characteristics (presence of comorbidities associated with increased risk of neuropathy, such as diabetes, depression, insomnia or genetic particularities) are some of the several factors that may influence on the onset of CIPN and the severity of symptoms

Initial pharmacologic treatments for neuropathic pain in diabetes include gabapentinoids, serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and sodium channel blockers

The dose for IV vitamin B12 therapy can range from 1,000 to 5,000 mcg

Symptoms of Vitamin B12 Deficiency Vitamin B12 plays a key role in maintaining nerve health, producing red blood cells, and supporting DNA synthesis