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Although the opioid results are inconclusive, the findings regarding NSAIDs and neuromodulators were notable, suggesting that CO 2 laser treatment may serve as an effective solution, potentially encouraging patients to discontinue medications for pillar pain relief

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126 In an ALD mouse model, combined Lactobacillus rhamnosus GG and metformin treatment corrected immune response dysregulation by enhancing the gut microbiome, restoring mucosal barrier integrity, regulating immune function, and reducing liver injury, thereby improving ALD