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Ferroptosis (iron-dependent lipid peroxidation) is also implicated as a mechanistic bridge by emerging evidence: GPX4 dysfunction and iron accumulation increase lipid peroxides, which sensitize neurons to ferroptotic death and provide extra DAMP-like signals that increase inflammasome activation [58, 59]

Nature 457:475479 Sjstrm PJ, Rancz EA, Roth A et al (2008) Dendritic excitability and synaptic plasticity

however, only a few studies have characterized the glutathione gene expression profiles 19,40

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