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2022;20;3:iqac003

NAFLD, increasingly prevalent in the context of rising obesity rates, involves fat accumulation in liver cells without significant alcohol consumption and can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and liver failure [3]

The redox cycling enzymes thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GSH peroxidase, superoxide dismutase 1, and catalase, and several GSH S-transferases, which are the enzymes mediating the elimination of ROS, are all Nrf2 targets (242)

Mechanistically, the induction of ferroptosis is intricately associated with an imbalance between the oxidative and antioxidant systems within the organism