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10.1016/j.ajo.2021.06.022 189 WeerawatanakornM.KamchonemenukoolS.KohY.-C.PanM.-H

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Reconstitution Math: 5mg Vial Add 2.5mL of BAC water to a 5mg (5,000mcg) vial: 5,000mcg 2.5mL = 2,000mcg per mL On a standard U-100 insulin syringe (100 units = 1mL): 300mcg dose = 0.15mL = 15 units 250mcg dose = 0.125mL = 12.5 units 500mcg dose = 0.25mL = 25 units 1,000mcg dose = 0.5mL = 50 units Reconstitution Math: 2mg Vial Add 2mL of BAC water to a 2mg (2,000mcg) vial: 2,000mcg 2mL = 1,000mcg per mL On a U-100 insulin syringe: 300mcg dose = 0.3mL = 30 units 250mcg dose = 0.25mL = 25 units 200mcg dose = 0.2mL = 20 units Step-by-Step Reconstitution Process Gather and prep Wash hands thoroughly

The efficacy and safety of the treatment with different combinations versus treatment with either agent alone has been investigated by different groups in large mulitcentral trials [95, 96]