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Annual Review of Microbiology 50: 137181

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Pulmonary fibrosis and pulmonary hypertension (PAH) are observed in most of these patients due to increased serum levels of TNF- (92)

Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany NNMT inhibition, establishing a fuller picture of the enzyme's regulatory network