glutathione s-conjugate X-ray structure of S-transferase from the malarial parasite Plasmodium falciparum Enzymatic Conjugation of Erythrocyte Glutathione

Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes

Dambach DM, Watson LM, Gray KR, Durham SK, Laskin DL

Additionally, ROS act as second messengers, activating various signal transduction pathways that can lead to cellular and tissue damage, organ dysfunction, and even carcinogenesis

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