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However, unfortunately, although in vitro and in vivo experiments have clarified Fer-1s protective effect on the DR retina and its ferroptosis-regulating mechanism, corroborating the clinical potential of ferroptosis-targeted intervention, critical limitations remain in its targeting specificity, potential off-target risks and clinical translational potential of preclinical models

Screening of overlap genes and functional annotation In this study, the R package limma was used to calculate the fold change value of gene expression level to uncover the overlapping genes of various SAAM groups

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