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Further research is needed to clarify how these differences translate into clinical safety and efficacy.16 Pharmacokinetics and pharmacodynamics The area under the plasma concentrationtime curve (AUC) and maximum plasma concentration (Cmax) of ritlecitinib increase approximately proportionally with dose up to 200mg, with a terminal half-life ranging from 1.3 to 2.3h

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6 Conclusion PD is a multifactorial neurodegenerative disorder, with neuroinflammation and ferroptosis playing critical roles in its pathogenesis