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5 Conclusion This architecture offers a framework for integrative computational models to prioritize Table 1 candidates, similar to validated precedents, with experimental calibration needed for translation. In previous work, a molecular systems architecture of pancreatic cancer was successfully used to develop computational models that predicted dosages of a two-drug combination that was allowed by the U.S

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In a similar way, the combination of PI3K inhibitors with ERK inhibitors (38), MEK inhibitors (NCT01363232, NCT01337765, NCT01392521, NCT01390818) or RAF inhibitors are being tested with promising results in early clinical trials

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