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By incorporating this covalent handle onto a diverse set of protein-binding ligands, degradation of various proteins, such as CDK4, BRD4, BCR-ABL, c-ABL, PDE5, AR, AR-V7, BTK, LRRK2, HDAC1/3 and SMARCA2/4, has been achieved

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For PB reaction method, both shotgun analysis 25,34 and HPLC-PB-MS/MS workflow 30 have been developed for identifying a large number of C=C location isomers