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Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development

Several factors can lead to the uncontrolled production of ROS, including damage to the mitochondrial complex I and III, which are the major sources of ROS, reduced ATP production, or malfunctioning of enzymes such as superoxide dismutase (SOD) that convert ROS into non-toxic molecules (Elfawy and Das, 2019)

Aliment Pharmacol Ther 26: 757766, 2007

Previously, a number of preventive and therapeutic polyclonal and monoclonal antibodies have been under research in academic laboratories, aimed at viral infections caused by rotavirus, Hantaan virus, parvovirus, yellow fever virus