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For subsequent anticancer therapy, after achieving sustained HBV DNA suppression with antiviral therapy and complete normalization of liver function, a switch to an alternative CDK4/6 inhibitor (e.g., palbociclib, ribociclib, or abemaciclib) may be considered following multidisciplinary team (MDT) discussion ( Conclusion For patients with HR+/HER2- advanced or metastatic breast cancer treated with dalpiciclib, pre-treatment evaluation of HBsAg and/or HBV DNA levels is mandatory