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9.2 Production-system and geographic diversity in resistance Notably, there is a great geographical variation in the development and severity of ivermectin resistance, which is attributable to the regional disparities in the types of parasites, climatic conditions, production systems, and the practice of drug use

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S1A, S1B), an effect we attribute to the de-repression of the T7 promoter during extended growth at 37C (Grossman et al ., 1998)