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However, many trials suffered from poorly considered experimental designs, and future studies need to pay attention to assessing several factors, such as the different types of SCFA (acetic acid, propionic acid, butyric acid, or mixtures thereof), the form of SCFA administration (fiber-rich diets or capsules containing sodium salts or inulin esters), the duration of the intervention, the route of administration (oral or intravenous infusion), and patient adherence

Br J Nutr 102(8):11211124 Pope SD, Medzhitov R (2018) Emerging principles of gene expression programs and their regulation

In addition, it now allows us to address the extent to which heteroplasmy is preserved in specific cell types during the differentiation process