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For example, chlorpromazine (CPZ) (183) is the first generation of antipsychotics, which is mainly used to treat schizophrenia and other mental diseases

Although it is well characterized that pathological -synuclein propagates in a prion-like fashion from the stomach and duodenum to the brain via the vagus (Van Den Berge et al., 2019), how the appendix facilitates the pathological spread is unanswered since the evidence shows increased levels of -synuclein with significant enrichment within the axonal varicosities of the mucosal plexus ( via DNA methylation of genes related to the production of autophagic protein and lysosomal degradation pathways (Figure 3A) ( in vivo , thereby increasing the risk of developing PD (Wang et al., 2018)

Vetere G, Cautino SC, Yousef MM, Payapwattanawong S, Agrawal N, Roy P, Abraham S, Alfaro K, Maddalena G, Alshenaifi JY, Parseghian C, Van K Morris II, Singh Raghav KP, Willis J, Overman MJ, Dasari A, YC Shen JP, Shen X, Kopetz S , Osterlund E

Drug-induced mast cell eradication: a novel approach to treat mast cell activation disorders