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MRM multiple reaction monitoring the 1-MNA NNMT reaction product was quantified from peak area ratios using AB Sciex Analyst and MultiQuant 2.1 software and the parent precursor and Q3 masses set to m/z 137.1 and 94.1, respectively

Increased expression of the ectoenzyme CD38 in peripheral blood plasmablasts and plasma cells of patients with systemic sclerosis

Monitoring response to treatment involves: Clinical assessment of symptom improvement, including mouth ulcer frequency FBC to confirm resolution of anaemia and reticulocyte response Ongoing monitoring of neurological symptoms if present Routine repeat measurement of serum B12 levels shortly after starting injections is not generally recommended as results may be misleadingly high

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