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Lancet 396:12041222

[DOI] [PubMed] [Google Scholar] 80.Didangelos T., Karlafti E., Kotzakioulafi E., Margariti E., Giannoulaki P., Batanis G., Tesfaye S., Kantartzis K

Upon uptake by recipient immune cells, such as macrophages and cytotoxic T lymphocytes, ROS-induced exosomal miRNAs can promote M2 macrophage polarization and suppress CD8 T-cell function, effectively extending immunosuppressive signaling beyond the tumors immediate vicinity [309]

Additionally, autophagy-related 2 A (ATG2 A) and WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), which are involved in the initiation of autophagy, were downregulated