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doi: 10.1073/pnas.1304790110 111 De VeirmanKMenuEMaesKDe BeuleNDe SmedtEMaesAet al

ALA and B12 are different nutrients with different roles

It also reduced the release of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1, which were triggered by ethanol exposure, improved energy homeostasis in the ileum, and reversed the downregulation of mRNA and protein expression of key tight junction proteins in the ileum, specifically ZO-1, Claudin-1, and Occludin, thereby restoring their functional integrity

When the level of ROS increases, low intensity, intermediate, and high intensity oxidative stress can occur (Lushchak, 2014a)