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[591] For purposes of the Shared Savings Program's reopening policy, we may find there is reliable evidence of similar fault when a demanded overpayment determination was issued to a provider or supplier for which CMS has revoked or deactivated their Medicare billing privileges, or for which there is a closed law enforcement investigation, among other possible factors

6.1 The vascular endothelial dysfunction Endothelial cells line the inner layer of blood vessels and play critical roles in regulating vascular tone, maintaining blood flow, and providing anticoagulant properties

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The condition may be due to weakness of the supporting tissue