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These include the thioredoxins and glutaredoxins, but we are also characterizing alternative pathways for disulfide bond reduction

She Q, Shi P, Xu SS, Xuan HY, Tao H, Shi KH, Yang Y

Previous studies have demonstrated that rapamycin, an inhibitor of mTOR, reduces GPX4 protein expression and promotes ferroptosis and autophagy 9,10

The no observed adverse effect level (NOAEL) was determined to be 540 mg/kg, equivalent to 24 times the human clinical dose (448 mg/person/28 days), supporting the safety margin of rotigotine behenate loaded in PLGA microspheres and its potential for advancement into phase I clinical trials for PD 137