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However, gemcitabine alone, or in combination with HGF/c-MET inhibition, significantly reduced proliferation

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

Supports endothelial cell proliferation and migration : VEGFR2 modulation is associated with increased fibroblast activity and early connective tissue regeneration in transected ligament models 4