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They were synthesized via a facile sonochemical procedure

Furthermore, a near-complete depletion of CD20 + B cells in minor salivary glands and a greater and more sustained depletion of peripheral CD19 + B cells were observed with belimumab combined with rituximab compared to monotherapies (104)

While the median time of developing autoimmune breakthrough, adverse events vary from 3 to 12 weeks depending on the organ system involved, these toxicities may present themselves earlier in those with underlying conditions