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These findings suggest that loss of PDI functional activity can directly lead to apoptosis, or indirectly, to a range of cellular abnormalities, such as oxidative stress, protein misfolding, as well as cell death (Jeon et al., 2014)

Previous studies have theoretically and experimentally demonstrated the positive therapeutic effects of modulating oxidation in viral CAPs, such as COVID-19, but there is a relative lack of more relevant clinical studies to further clarify the clinical efficacy in CAP infection caused by other pathogens

Hypotonic and crystal activation of LRRC8 mediates ATP release by macrophages We next investigated the mechanisms by which LRRC8 can regulate NLRP3 inflammasome activation

J Frailty Aging