glutathione mtorc Molecular Medicine Reports reduced glutathione and breast cancer

Deficiency of amino acids, glutathione reductase or glutathione peroxidase) Follow Oxidative and nitrosative (NO) stress Energy shortage Thiol group deficit (-SH) Detoxification disorders Immunosuppression and susceptibility to infection Reperfusion injury, increased hemolysis rates neurological, psychomotor, cardiovascular, ocular and hepatic disorders Glutathione diagnostics Nutritional and lifestyle history Specific symptoms Laboratory test Total glutathione (erythrocytes): 1805-3600 mol/l GSH reduced (leukocytes or erythrocytes): 962-3329 mol/l GSH:GSSG ratio (serum): 99:1 to 90:10 (no information about the intracellular situation) Glutathione peroxidase: 4170-10880 U/L In cases of stress/illness, the GSH/GSSG ratio shifts first

10.1093/advances/nmab127 62 TanS.LiuQ.YangJ.CaiJ.YuM.JiY.et al (2022)

ROS can damage cellular components such as lipids, proteins, and DNA, leading to cell death and loss of cardiac contractile function

A reasonable hypothesis is that the rapid cycling allows the liver to respond quickly to the glutathione requirements of other tissues