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News Six Victorian cases have been linked to the unapproved drugs, as Australias CMO sounds the alarm on the escalating health threat

Introduction Colorectal cancer (CRC) is the second leading cause of cancer related death and the third most commonly diagnosed in the world, with 1.8 million new cases in 2018 ( MMR ) genes and in Wnt (APC) , TGFbeta/BMP signalling pathways (e.g., MADH4, SMAD4, BMPR1A ) predispose to hereditary CRC syndromes ( BMP2, BMP4, SMAD7, CCND2, GREM1 ) and in genes not previously linked to CRC (CDKN1A, EIF3H, TPD52L3, ITIH2, LAMA5, and LAMC1 ) ( Thus, the potential preventability of CRC depends on detailed understanding of its aetiology and interactive underlying mechanisms of development

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