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Moreover, the effort to find the therapeutic targets from multiple dimensions may provide new ideas for the prevention and treatment of HUA-related nephropathy

Our results showed that 10 M BAY 11-7082 effectively inhibited the nuclear translocation of NF-B p65 and the mRNA expression of Bax and P53 , but increased the mRNA expression of Bcl2 and Bcl-xL in the peroxynitrite + BAY 11-7082 group compared with the peroxynitrite-only group, as well as in the peroxynitrite + gpx1 / + BAY 11-7082 group compared with the peroxynitrite + gpx1 / group (Figures 9AC)

Commonly discarded or used as fuel during parboiling, rice husk contains high levels of organic compounds such as lignin and cellulose, along with significant mineral content, particularly silica (143, 144)