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doi: 10.3389/fnut.2021.759507 Received 16 August 2021 Accepted 18 October 2021 Published 25 November 2021 Volume 8 - 2021 Edited by Xian Wu, Miami University, United States Reviewed by Maria Elisa Drago-Serrano, Universidad Autnoma Metropolitana Unidad Xochimilco, Mexico

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Typical subcutaneous dosing ranges from 1-3 mg daily or 3-5 times per week, often cycled in 8-12 week protocols with 4-week breaks to prevent receptor downregulation or copper accumulation