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Resolving these gaps is essential not only to delineate the mechanisms driving NVU failure, but also to identify precise, human-relevant targets for interventions aimed at preserving vascular integrity and slowing neurodegeneration in PD

Additionally, cross-species comparisons highlight interspecies differences, helping to mitigate the risk of candidate attrition during development

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Conclusion: Our study supports previous reports of overestimation of hepatic steatosis with traditional methods and shows similar overestimation using Banff criteria