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The sample was small (10 subjects per group)

Mafra D, Borges N, Alvarenga L, Esgalhado M, Cardozo L, Lindholm B

From extraction to advanced analytical methods: the challenges of melanin analysis

The fibrosis and vasoconstriction that accompany this aberrant vascular remodeling response raise the pressure in the pulmonary arteries, which ultimately leads to early death