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Another Gln transporter SLC1A5 inhibitor, V-9302, selectively blocked Gln uptake by TNBC cells, promoted the activation of CD4 + and CD8 + T cells, and reduced Treg levels in a TNBC mouse model (Table 1)

10.1186/s43045-023-00315-3 213 JenkinsT.NguyenJ.PolglazeK.BertrandP

This action causes macrophages to polarize towards an M1 phenotype and lymphocytes mount a cytotoxic T cell response to eliminate target cells 30

Interestingly, the early (3.5 days) slight (0.5-fold more than controls, while the peak was 7-fold) but significant increase in Enpp6 -positive newly-forming/formed OLs was accompanied by a concomitant and very comparable degree of decrease (52%) in Pdgfra -positive OPCs, with the specific values of 50 per mm 2 increase for Ennp6 -positive cells, and 80 per mm 2 decrease for Pdgfra -positive cells