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Brain lesions stimulate production of IGF-1 and estrogen by reactive astrocytes, and increase ER and IGF-1R expression in activated glial cells (Garcia-Estrada et al., Consistent with the important interactions between estrogen and brain IGF-1 system, gender differences have been observed in several responses mediated by IGF-1 such as effects of exercise (Munive et al., Interaction between IGF-1 and RAS in Neuroinflammation As in the case of IGF-1, the brain RAS has been associated with longevity, neuroinflammation and aging-related neuronal vulnerability to degeneration (Labandeira-Garcia et al., Mutual regulation between RAS and IGF-1 was observed in peripheral cells, particularly in vascular smooth muscle cells (Ma et al., According to previous observations in plasma, and other brain regions and tissues (Bartke et al., 2012, 2014), a counterregulatory increase rather than a decrease in IGF-1 levels may be expected

Kim et al., 2011

It has been 8 years and up until this year he has been doing pretty good