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Per- and poly-fluoroalkyl substances (PFAS) have been shown to reduce circulating thyroid hormone levels by interfering with intracellular signaling cascades, like mitogen-activated protein kinase (MAPK) pathway, which can alter thyroid hormone production, secretion, and cellular responses (93)

Mazdutide A phase II, randomized, double-blind, placebo-controlled trial showed moderate weight loss with mazdutide in Chinese patients with overweight or obesity without T2DM)

These insights reveal a dual pathogenic role of BAX/BAK-mediated MOMP in neurological diseases beyond executing apoptosis: it can directly promote mtDNA release, which can activate neuroinflammation and drive disease progression

This should also concern an in-depth analysis of the mechanism of action, including NO as the target most affected by the peptide, as well as the off-targets and their possible effects