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Ferroptosis is an iron-dependent lipid peroxidation-mediated cell death

Additionally, pinocembrin has been shown to restore cognitive function and reduce neuronal apoptosis and hippocampal inflammation in vivo, mainly by inhibiting NLRP3 inflammasome formation, reducing microglial infiltration, and enhancing BNIP3-mediated mitophagy through the JNK-ERK signaling pathway [175]

Combination of ursodeoxycholic acid and glycyrrhizic acid (Phosphogliv URSO) in the treatment of nonalcoholic fatty liver disease: results of a multicenter randomized clinical trial on efficacy and safety