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In contrast, the most recent studies have shown an increase in tumor development and metastasis in mouse models treated with vitamin E 155 (an opposite result of that in which high doses of vitamin C increase ROS levels to induce the death of colon cancer cells bearing KRAS and BRAF mutations) 156

[DOI] [PubMed] [Google Scholar] 152.Heunks LM, Machiels HA, Dekhuijzen PN, Prakash YS, Sieck GC

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