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Nat Rev Neurosci 10(7):508523

In neither dosage ST could prevent histological changes in the liver, but the kidney and the heart were not affected

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The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks