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In a randomized placebo-controlled trial in 71 people with NAFLD, 300 mg delta-tocotrienol twice daily for 24 weeks reduced insulin resistance and fatty liver index scores

PubMed Abstract | Publisher Full Text 298

Metformin also modulates other critical pathways, dampening integrin/ERK signaling, limiting matrix-degrading enzymes, and protecting enlarged fat cells from premature death (334)