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This metabolism, which is oriented toward the synthesis of phosphoadenosine phosphosulfates from homocysteine thiolactone sulfur atoms, might lead to an excessive sulfation of extracellular matrix proteoaminoglycans

Nutrition: Maintain adequate dietary fats for steroid-hormone synthesis and sufficient protein and micronutrients (zinc, vitamin D, magnesium)

Similar trends were also found among other populations, although no statistically significant difference was found in some genetic models

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition