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8 Holotranscobalamin (holoTC) has been reported to offer slightly better performance than total serum B 12 levels in diagnosing deficiency, but these study designs have been criticized, and there is currently no consensus that holoTC should replace conventional serum B 12 testing

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Vasan RS, Sullivan LM, DAgostino RB et al (2003b) Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study

Another case study reported that high-dose oral thiamine supplementation (750 mg/day) improved the symptoms of chronic cluster headache, and confirmed its role in pain modulation (21)