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doi: 10.3389/fphys.2014.00084

doi:10.11124/jbisrir-2015-1987 [3] Piantanida E, Ippolito S, Gallo D, et al

There are multiple strategies to create a knockout mouse model, such as embryonic stem (ES) cells and clustered regularly interspaced short palindromic repeats (CRISPR), all with the aim to prevent the translation of the genes full length wild-type sequence