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One potential explanation is group heterogeneity, in this case an inclusion of participants with different biological backgrounds despite similar clinical presentations, which might lead to a decrease in power to detect changes, especially if these are subtle

It is also important to note that a prior randomized, placebo-controlled, double-blind study of LAC treatment for probable AD patients showed that administration of LAC was associated with lower AD-related deterioration as assessed using the clinical dementia rating scale and mini-mental scale examination in those subjects younger than 65 years [65, 66]

(2000) 72(2 Suppl.):618S23S

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