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In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 (Kwon et al., 2019)

Indeed, it was demonstrated that heterodimerization of 1-cysPrx with GSH-saturated GSTP results in S -glutathionylation of the oxidized cysteine in 1-cysPrx followed by subsequent spontaneous reduction of the mixed disulfide and restoration of enzymatic activity ( GSH AND NITROSATIVE STRESS Besides protecting against ROS, GSH is implicated in counteracting RNS-mediated damage

More is not always better, especially with fat soluble vitamins such as D and E

Moreover, DNAm has been implicated in cognitive decline associated with aging and AD [34,35,36], suggesting it may serve as a potential marker through which lifestyle factors influence cognition