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Markram et al., 1997)

These molecules interact with receptors on meningeal blood vessels and the dura mater, causing vasodilation, activation of nociceptive fibers, and an inflammatory response (8, 12)

1 Epinephrine Injection, USP is indicated for emergency treatment of allergic reactions (Type I), including anaphylaxis, which may result from insect stings or bites, foods, drugs, sera, diagnostic testing substances, and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis