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It is formed by the chelation of zinc ions with methionine

Parazzini F, Cipriani S, Bianchi S, et al

Occasionally, procyanidin dimers, but no trimers have been reported in plasma

In contrast, treatment with an ICS will reduce airway inflammation, which is in itself the major cause for asthmatic exacerbations, that include airway remodeling, hyper-reactivity and bronchoconstriction (see Figure 2)