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In 2013, a clinical trial of ketamine in treatment-resistant depression used midazolam as an active placebo, finding 64% responders for ketamine and 28% for midazolam (Murrough et al., 2013), while the antidepressant effect was also confirmed to occur in bipolar depression ( NMDA inhibitors such as phencyclidine (PCP) were identified in the 1980s, and noted to cause psychosis (Olney et al., 1999)