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doi: 10.3233/JAD-190083, 147

Overexpression of MT1G inhibits the proliferation, migration, and invasion functions of GC cells, reduces SOD and GSH content, increases MDA content, cause the mitochondrial membrane potential to weaken and promote the transformation of JC-1 aggregates to JC-1 monomer, increases Fe 2+ , affects ROS, and reduces GPX4 and SLC7A11 protein expression, promoting ferroptosis

ChenKXieKLiuZNakasoneYSakaoKHossainMAet al

While the human host is a very different habitat in comparison with soil or excrements of animals that are the most common natural niche for this group of fungi, interactions with other eukaryotes in the environment likely selected for some properties that also predisposed species to become pathogenic to humans