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Cladribine, gemcitabine, lovastatin and tamoxifen have an inhibitory effect on melanoma cell lines in vitro, also in combination with conventional targeted kinase inhibitors To identify the most promising drug candidates for in vitro testing, we filtered the predicted drugs based on their predicted efficacy, prior evidence from high-throughput CRISPR [34] and drug screens [35], IC 50 values in melanoma and other cancer types, known metabolic targets, mechanisms and availability of clinical trial data in phase II or higher (Table 2 and Supplementary File 2)

Phytochemistry 67, 14271434