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Experimental design considerations include the importance of timing senolytic administration relative to senescence induction or disease progression, as the biological context affects both efficacy and interpretation of results

[45] Many members of the flavonoid family, including quercetin, fisetin, rutin, apigenin, luteolin and kaempferol have all been found to have some degree of senolytic efficacy

The negative results of the latter study may, at least partly, be due to the large heterogeneity of causes of AKI (trauma, hypertension, surgery, drugs or sepsis) and/or the delayed initiation of rhIGF-1 treatment, i.e., after established AKI

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